研究部門research department

　現在、慢性腎不全となり血液・腹膜透析を導入される患者は年間約3万人おり、この数は年々増えていく傾向にあります。末期腎不全の主な原因疾患である糖尿病腎症、慢性腎炎、さらには、超高齢化をむかえた本邦においては、加齢や動脈硬化に伴う慢性腎臓病患者が増加の一途を示しており、その発症・進展機序の一刻も早い解明が期待されています。私達臨床医の義務と考える基礎研究と臨床との相互のフィードバック（From Bench to Bedside, From Bedside to Bench）を念頭におき、これら病態の解明のために分子生物学的手法を駆使し研究を行っています。

研究メンバー

上田誠二（特任教授） 1995 久留米大学卒

長澤　肇（特任助教） 2014 金沢医科大学卒 

　　　　　　　　　　 2022 順天堂大学医学部大学院医学研究科卒

大熊輝之（特任助教） 2016 聖マリアンナ医科大学卒

　　　　　　　　　　 2024 順天堂大学医学部大学院医学研究科卒

研究テーマ

• 糖尿病腎症の発症進展機序の解明に関する研究
• 心腎連関脳腎連関病態に関する研究
• 尿毒症物質や血管作動物質の動脈硬化、血管老化に関する研究
• 腎老化、腎線維化に関する研究
• 尿毒症性サルコペニアの発症機序、治療に関する研究
• 高血圧や慢性腎臓病におけるレニンアンジオテンシンアルドステロン系、エンドセリン、NOなどの血管作動物質や交感神経系の制御に関する研究

主な研究業績

1. Nagasawa H, Ueda S, Suzuki H, Jenkinson C, Fukao Y, Nakayama M, Otsuka T, Okuma T, Clapper W, Liu K, Nguyen M, Komers R, Suzuki Y.　 Sparsentan is superior to losartan in the gddY mouse model of IgA nephropathy. Nephrol Dial Transplant. 2024 in press. doi: 10.1093/ndt/gfae021. 
2. Wing-Shing Fung W, Park HC, Hirakawa Y, Arruebo S, Bello AK, Caskey FJ, Damster S, Donner JA, Jha V, Johnson DW, Levin A, Malik C, Nangaku M, Okpechi IG, Tonelli M, Ueda S, Ye F, Suzuki Y, Wang AY; Regional Board and ISN-GKHA Team Authors.　 Capacity for the management of kidney failure in the International Society of Nephrology North and East Asia region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA).　 Kidney Int Suppl (2011). 2024;13:97-109.
3. Suzuki Y, Kaneko H, Nagasawa H, Okada A, Fujiu K, Jo T, Takeda N, Morita H, Nishiyama A, Gohda T, Suzuki Y, Node K, Yasunaga H, Nangaku M, Komuro I.　 Comparison of estimated glomerular filtration rate change with sodium-glucose cotransporter-2 inhibitors versus glucagon-like peptide-1 receptor agonists among people with diabetes: A propensity-score matching study Diabetes Obes Metab. 2024 in press. doi: 10.1111/dom.15561
4. Nagasawa H, Kaneko H, Suzuki Y, Okada A, Fujiu K, Takeda N, Morita H, Nishiyama A, Yano Y, Node K, Viera AJ, Carey RM, Oparil S, Yasunaga H, Touyz RM, Komuro I. Association of cancer with the risk of developing hypertension. Eur Heart J Qual Care Clin Outcomes. 2024 in press. doi: 10.1093/ehjqcco/qcad036.
5. Nagasawa H, Ueda S, Otsuka T, Kaifu K, Ono S, Okuma T, Kobayashi T, Matsushita S, Kasai T, Dohi T, Fukushima Y, Amano A, Suzuki Y. Safety and efficacy of using cereal food (Frugra®) to improve blood pressure and bowel health in patients undergoing chronic hemodialysis: A pilot study. J Pharmacol Sci. 147(1):132-137, 2021
6. Yabuuchi J, Ueda S, Yamagishi SI, Nohara N, Nagasawa H, Wakabayashi K, Matsui T, Yuichiro H, Kadoguchi T, Otsuka T, Gohda T, Suzuki Y.  Association of advanced glycation end products with sarcopenia and frailty in chronic kidney disease Sci Rep. 10:17647, 2020
7. Takahashi K, Ueda S, Kobayashi T, Nishiyama A, Fujisawa Y, Sugaya T, Shiota S, Takahashi K, Gohda T, Horikoshi S, Suzuki Y. Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease. Sci Rep. 8: 17926, 2018.
8. Yokoro M, Nakayama Y, Yamagishi S, Ando R, Sugiyama M, Ito S, Yano J, Taguchi K, Kaida Y, Saigusa D, Kimoto M, Abe T, Ueda S, Fukami K. ADMA contributes to the impaired response to erythropoietin in CKD-Anemia. J Am Soc Nephrol. 28: 2670-2680, 2017.
9. Tsuprykov O, Ando R, Reichetzeder C, von Websky K, Antonenko V, Sharkovska Y, Chaykovska L, Rahnenführer J, Hasan AA, Tammen H, Alter M, Klein T, Ueda S, Yamagishi S, Okuda S, Hocher B.　The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5/6 nephrectomy.　 Kidney Int. 89: 1049-1061, 2016
10. Koike K, Ueda S, Yamagishi S, Yasukawa H, Kaida Y, Yokoro M, Fukami K, Yoshimura A, Okuda S. Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstruction. Clin Immunol. 150: 78-87, 2014.
11. Nakayama Y, Ueda S, Yamagishi S, Obara N, Taguchi K, Ando R, Kaida Y, Iwatani R, Kaifu K, Yokoro M, Toyonaga M, Kusumoto T, Fukami K, Okuda S: Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury. Kidney Int. 85: 570-578, 2014
12. Fujimi-Hayashida A, Ueda S, Yamagishi S, Kaida Y, Ando R, Nakayama Y, Fukami K, Okuda S: Association of ADMA with severity of kidney injury and decline in kidney function in IgA nephropathy. Am J Nephrol. 33:1-6, 2011
13. Shibata R, Ueda S, Yamagishi S, Kaida Y, Matsumoto Y, Fukami K, Hayashida A, Matsuoka H, Kato S, Kimoto M, Okuda S: Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischemia in early phase of diabetic nephropathy. Nephrol Dial Transplant. 24: 1162-1169, 2009
14. Matsumoto Y, Ueda S, Yamagishi S, Matsuguma K, Shibata R, Fukami K, Matsuoka H, Imaizumi T, Okuda S: Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease. J Am Soc Nephrol. 18:1525-1533, 2007
15. Matsuguma K, Ueda S, Yamagishi S, Matsumoto Y, Kaneyuki U, Shibata R, Fujimura T, Matsuoka H, Kimoto M, Kato S, Imaizumi T, Okuda S: Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease. J Am Soc Nephrol. 17:2176-2183, 2006
16. Ueda S, Yamagishi S, TakeuchiM, KohnoK, ShibataR, MatsumotoY, KaneyukiU, FujimuraT, HayashidaA, OkudaS: Oral adsorbent AST-120 decreases serum levels of AGEs in patients with chronic renal failure. Mol Med, 12:180-184,2006
17. Fukami K, Ueda S, Yamagishi S, Kato S, Inagaki Y, Takeuchi M, Motomiya Y, Bucala R, Iida S, Tamaki K, Imaizumi T, Cooper ME, Okuda S: AGEs activate mesangial TGF-beta-Smad signaling via an angiotensin II type I receptor interaction. Kidney Int. 66:2137-2147, 2004
18. Ueda S, Matsuoka H, Miyazaki H, Usui M, Okuda S, Imaizumi T: Tetrahydrobiopterin restores endothelial function in chronic smokers.  J Am Coll Cardiol. 35: 71-75, 2000
19. Ueda S, Kato S, Matsuoka H, Kimoto M, Okuda S, Morimatsu M, Imaizumi T: Regulation of cytokine-induced nitric oxide synthesis by asymmetric dimethylarginine: role of dimethylarginine dimethylaminohydrolase. Circ Res. 92:226-233, 2003
20. Miyazaki H, Matsuoka H, Usui M, Ueda S, Okuda S, Imaizumi T: Hemodialysis impairs endothelial function via oxidative stress – effect of vitamin E-coat dialyzer- Circulation 101: 1002-1006, 2000
21. Miyazaki H, Matsuoka H, Usui M, Ueda S, Okuda S, Imaizumi T:  Endogenous nitric oxide synthase inhibitor, a novel marker for atherosclerosis.  Circulation 99:1141-1146, 1999